Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrated cross-organ transcriptomic analysis uncovers conserved gene signatures predictive of allograft rejection.

PloS one·2026

Same author

Contrasting low- and high-resolution features for HER2 scoring using deep learning.

Journal of pathology informatics·2025

Same author

Hypometabolism in Autism Spectrum Disorder: Insights from Brain and Blood Transcriptomics.

Molecular neurobiology·2025

Same author

A single-cell network approach to decode metabolic regulation in gynecologic and breast cancers.

NPJ systems biology and applications·2025

Same author

IPD-Brain: An Indian histopathology dataset for glioma subtype classification.

Scientific data·2024

Same author

Devising Isolation Forest-Based Method to Investigate the sRNAome of <i>Mycobacterium tuberculosis</i> Using sRNA-seq Data.

Bioinformatics and biology insights·2024

Search research articles

Related Experiment Video

Updated: Aug 21, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

Inferring miRNA sponge modules across major neuropsychiatric disorders.

Rami Balasubramanian¹, P K Vinod¹

¹Centre for Computational Natural Sciences and Bioinformatics, International Institute of Information Technology, Hyderabad, India.

Frontiers in Molecular Neuroscience

|November 17, 2022

Summary

Researchers mapped the microRNA (miRNA) sponge network in neuropsychiatric disorders (NPDs), identifying long non-coding RNAs (lncRNAs) as potential diagnostic biomarkers. This network offers insights into NPD mechanisms and therapeutic targets.

Keywords:

co-expression network miRNA sponge modules network biology neuropsychiatric disorders (NPD)non-coding RNAs

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Related Experiment Videos

Last Updated: Aug 21, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Area of Science:

Neuroscience
Genetics
Molecular Biology

Background:

Non-coding RNAs, particularly long non-coding RNAs (lncRNAs), play a crucial role in gene regulation.
Dysregulation of lncRNAs and microRNAs (miRNAs) is implicated in the pathophysiology of neuropsychiatric disorders (NPDs).
lncRNAs can act as miRNA sponges, sequestering miRNAs and thereby influencing the expression of target messenger RNAs (mRNAs).

Purpose of the Study:

To construct a comprehensive lncRNA-miRNA sponge network across multiple NPDs, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD).
To identify key miRNA sponge modules and their associated biological pathways relevant to NPDs.
To discover potential lncRNA biomarkers for NPD diagnosis.

Main Methods:

Large-scale inference of the lncRNA-miRNA sponge network using brain transcriptomic (RNA-Seq) data from patients with NPDs.
Identification of candidate miRNA sponge modules based on co-expression patterns, shared miRNA binding sites, and canonical correlation analysis.
Validation of identified modules in independent brain and blood transcriptomic datasets.

Main Results:

The study identified numerous miRNA sponge modules associated with critical biological processes, including synaptic transmission, nervous system development, metabolism, and immune response.
These modules exhibited condition-specific expression patterns across different NPDs.
The identified miRNA sponge modules were conserved across independent datasets, suggesting robustness.
Several lncRNAs involved in miRNA sponging were highlighted as potential diagnostic biomarkers for NPDs.

Conclusions:

The constructed lncRNA-miRNA sponge network provides valuable insights into the molecular mechanisms underlying NPDs.
The identified lncRNAs represent promising candidates for diagnostic biomarkers and potential therapeutic targets for NPDs.
This study offers a comprehensive resource for further research into the role of non-coding RNAs in neuropsychiatric conditions.