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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents

Belén Martinez-Gualda1,2, Mirthe Graus2, Anita Camps2

  • 1KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Leuven, Belgium.

Frontiers in Chemistry
|November 17, 2022
PubMed

Keywords:
7-aza-indoleVenezuelan equine encephalitis virus (VEEV)adaptor-associated kinase 1pyrrolo[2,3-b]pyridinerespiratory syncytial virus (RSV)severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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