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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-IV: Diagnostic and Management01:30

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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Atopic March: Dermatologic Perspectives.

Sandipan Dhar1, Soumya Jagadeesan2

  • 1Department of Pediatric Dermatology, Institute of Child Health, Kolkata, West Bengal, India.

Indian Journal of Dermatology
|November 17, 2022
PubMed
Summary
This summary is machine-generated.

The atopic march describes allergic disease progression from infancy to childhood. This review explores its epidemiology, immunology, and the skin

Keywords:
Allergic marchatopic dermatitisatopic marchskin barrier

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Area of Science:

  • Allergy and immunology research.
  • Dermatology and clinical practice.

Background:

  • The 'atopic march' describes the typical progression of allergic diseases.
  • This concept involves atopic dermatitis and food allergy in infancy, followed by asthma and allergic rhinitis in childhood.
  • The validity of the atopic march concept has been debated.

Purpose of the Study:

  • To review the latest epidemiology and immunological mechanisms of the atopic march.
  • To discuss the translational implications for clinical practice and research.
  • To highlight the skin's role in initiating allergic diseases and potential preventive interventions.

Main Methods:

  • Literature review of recent epidemiological data.
  • Analysis of immunological mechanisms underlying allergic disease progression.
  • Discussion of clinical and research implications.

Main Results:

  • The article synthesizes current understanding of the atopic march.
  • It emphasizes the skin as a potential site for allergic disease initiation.
  • It explores the possibility of skin-directed interventions to prevent later allergic conditions.

Conclusions:

  • The atopic march remains a significant concept in understanding allergic disease development.
  • The skin plays a crucial role, offering targets for early intervention.
  • Further research into skin-based prevention strategies is warranted for dermatologists.