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Hemostatic and Coagulation Profile in Psoriasis: A Hospital-Based case control Study
Mubashar M Mir1, Devraj Dogra1, Kuldeep K Koul2
1Post Graduate Department of Dermatology, Government Medical College, Jammu, Jammu and Kashmir, India.
Indian Journal of Dermatology
|November 17, 2022
Summary
Psoriasis patients show increased platelet activation and altered coagulation, indicated by higher mean platelet volume (MPV) and lower Vitamin B12 levels, correlating with disease severity and cardiovascular risk.
Area of Science:
- Dermatology
- Cardiology
- Hematology
Background:
- Psoriasis is a chronic inflammatory skin condition linked to increased cardiovascular disease and atherothrombosis risk.
- Understanding hemostatic and coagulation abnormalities in psoriasis is crucial for risk assessment.
Purpose of the Study:
- To evaluate hemostatic and coagulation parameters in psoriasis patients.
- To investigate the correlation between these parameters and psoriasis severity.
Main Methods:
- Observational hospital-based study including 75 psoriasis patients and 70 controls.
- Assessed Psoriasis Area and Severity Index (PASI), Platelet count (PC), mean platelet volume (MPV), Vitamin B12, Thrombin Time (TT), Prothrombin time (PT), and Activated partial thromboplastin time (APPT).
Main Results:
- Significantly elevated MPV and decreased Vitamin B12 levels were observed in psoriasis patients, correlating positively with disease severity (MPV) and inversely (Vitamin B12).
- Reduced PT, aPTT, and TT levels were noted in patients compared to controls, though without significant correlation to PASI.
- Increased MPV suggests heightened inflammation and platelet activation, while decreased Vitamin B12 may relate to atherothrombotic markers.
Conclusions:
- Inflammation in psoriasis may lead to abnormal platelet activation and coagulation.
- These hemostatic changes contribute to an atherothrombotic state, increasing cardiovascular risk in psoriatic individuals.
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