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Published on: January 28, 2020
The relationship between mean platelet volume lymphocyte ratio and collateral circulation in patients with chronic
Ming-Hui Niu1, Peng-Hui Liu1, Ze-Hua Liu1
1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Insights
The mean platelet volume lymphocyte ratio (MPVLR) is significantly higher in patients with poor coronary collateral circulation (CCC). A high MPVLR level independently predicts poorly formed CCC in patients with coronary chronic total occlusion (CTO).
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Coronary collateral circulation (CCC) is crucial for myocardial perfusion in patients with coronary chronic total occlusion (CTO).
- Factors influencing CCC formation are not fully understood, necessitating novel predictive markers.
- The mean platelet volume lymphocyte ratio (MPVLR) is a potential inflammatory marker.
Purpose of the Study:
- To investigate the correlation between MPVLR and the quality of CCC in patients diagnosed with CTO.
- To determine if MPVLR can serve as an independent predictor of poor CCC formation.
Main Methods:
- Retrospective analysis of 643 patients with CTO confirmed by coronary angiography.
- Patients were categorized into poorly formed CCC (Rentrop grade 0-1) and well-formed CCC (Rentrop grade 2-3) groups.
- MPVLR was calculated from routine laboratory data and compared between groups; logistic regression was used for analysis.
Main Results:
- Patients with poorly formed CCC exhibited significantly higher MPVLR compared to those with well-formed CCC (7.82 ± 3.80 vs. 4.84 ± 1.42, P < 0.01).
- High MPVLR was identified as an independent predictor of poorly formed CCC (OR: 2.101, P < 0.01).
- MPVLR demonstrated good predictive performance for poorly formed CCC with an AUC of 0.82.
Conclusions:
- MPVLR is negatively correlated with CCC in patients with coronary CTO.
- Elevated MPVLR levels are associated with poorly formed CCC and can serve as an independent predictor.
- MPVLR may represent a valuable, easily accessible biomarker for assessing collateralization in CTO patients.
Objective:
To correlate mean platelet volume lymphocyte ratio (MPVLR) and coronary collateral circulation (CCC) in patients with chronic total occlusion (CTO).
Materials And Methods:
A total of 643 patients who were hospitalized at a single large academic medical center from January 2020 to October 2021 and had CTO lesions in at least one major coronary artery confirmed by coronary angiography were retrospectively analyzed. Patients were divided according to the Rentrop criteria into poorly formed CCC (Rentrop grade 0-1, n = 235) and well-formed CCC (Rentrop grade 2-3, n = 408) groups. Mean platelet volume lymphocyte ratio (MPVLR) was calculated from routine laboratory data (MPV divided by lymphocyte count). The clinical data of the two groups were compared, and relationships between MPVLR and CCC formation were analyzed.
Results:
The MPVLR of patients with poorly formed CCC was significantly higher than that of patients with well-formed CCC (7.82 ± 3.80 vs. 4.84 ± 1.42, P < 0.01). The prevalence of diabetes mellitus and C-reactive protein levels were significantly higher in the poor CCC group than in the good CCC group (P < 0.01), while the proportions of patients with CTO or multivessel lesions in the right coronary artery were significantly lower in the poor CCC group than in the good CCC group (P < 0.01). Multivariate logistic regression analysis identified MPVLR (OR: 2.101, 95% CI: 1.840-2.399, P < 0.01), C-reactive protein level (OR: 1.036, 95% CI: 1.008-1.064, P < 0.05), a history of diabetes mellitus (OR: 2.355, 95% CI: 1.532-3.621, P < 0.01), and right coronary CTO ratio (OR: 0.313, 95% CI: 0.202-0.485, P < 0.01) as independent risk factors for CCC formation. The area under the ROC curve of MPVLR for predicting poorly formed CCC was 0.82 (95% CI: 0.784-0.855, P < 0.01), the best cut-off point was 6.02 and the sensitivity and specificity of MPVLR for predicting poorly formed CCC were 72.3 and 82.4%, respectively.
Conclusion:
In patients with coronary CTO, MPVLR was negatively correlated with CCC and a high MPVLR level was an independent predictor of poorly formed CCC.
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