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The relationship between atherosclerotic disease and relapse during ATD treatment

Xinxin Zhu1, Yaguang Zhang1, Xiaoyu Zhao1

  • 1Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Frontiers in Cardiovascular Medicine
|November 17, 2022
PubMed

Insights

Atherosclerotic disease is a significant risk factor for hyperthyroidism relapse in patients treated with antithyroid drugs (ATDs). Early identification and management of atherosclerosis are crucial for preventing relapse during ATD therapy.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Internal Medicine

Background:

  • Hyperthyroidism treatment with antithyroid drugs (ATDs) carries a risk of clinical relapse.
  • Atherosclerotic disease is linked to hyperthyroidism, but its association with ATD relapse is not well understood.

Purpose of the Study:

  • To investigate the relationship between atherosclerotic disease and relapse in patients with Graves' disease (GD) undergoing ATD treatment.
  • To identify independent risk factors for drug reduction relapse in GD patients.

Main Methods:

  • A cohort of 225 GD patients receiving initial ATD treatment was studied.
  • Logistic regression and Kaplan-Meier survival analysis were employed to assess risk factors and relapse rates.
  • Receiver Operating Characteristic (ROC) analysis evaluated the predictive accuracy of atherosclerotic disease.

Main Results:

  • Atherosclerotic diseases, elevated FT4 levels, goiter, and anxiety scores were identified as independent risk factors for relapse.
  • Patients with atherosclerotic disease, higher FT4, higher anxiety scores, or advanced goiter showed increased relapse risk.
  • Atherosclerotic disease significantly improved the predictive accuracy for relapse.

Conclusions:

  • Atherosclerotic disease is closely associated with hyperthyroidism relapse.
  • Hyperthyroid patients with atherosclerosis require increased attention during ATD treatment to mitigate relapse risk.
Abstract

Keywords:
Graves' diseaseantithyroid drugatherosclerotic diseasedrug reductionrisk factors

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