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The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease

Lin Cong1,2, Yunpeng Bai2,3, Zhigang Guo2,3

  • 1Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.

Frontiers in Cardiovascular Medicine
|November 17, 2022
PubMed

Insights

Cardiovascular disease (CVD) involves complex cell death mechanisms like autophagy, apoptosis, and pyroptosis. Understanding their interactions offers new therapeutic targets for treating CVD and improving patient outcomes.

Area of Science:

  • Biomedical research
  • Cardiovascular science
  • Cellular biology

Background:

  • Cell death mechanisms are crucial in cardiovascular disease (CVD) pathogenesis.
  • Autophagy, apoptosis, and pyroptosis are key cell death modes involved in CVD.
  • The interplay between these cell death pathways is not fully understood.

Purpose of the Study:

  • To review the interactions and crosstalk of key pathways and proteins in CVD.
  • To explore the specific mechanisms of autophagy, apoptosis, and pyroptosis in CVD.
  • To assess the interrelationships among these three cell death modes in regulating CVD pathogenesis.

Main Methods:

  • Literature review of recent research on cell death in CVD.
  • Analysis of key pathways and proteins involved in autophagy, apoptosis, and pyroptosis.
  • Synthesis of information on the collaborative regulation of CVD by different cell death modes.

Main Results:

  • Cell death modes like autophagy, apoptosis, and pyroptosis are interconnected and collaboratively regulate CVD.
  • Specific pathways and proteins mediating these interactions have been identified.
  • The crosstalk among these cell death mechanisms significantly influences CVD progression.

Conclusions:

  • Understanding the intricate relationship between autophagy, apoptosis, and pyroptosis is vital for elucidating CVD pathogenesis.
  • Identifying novel therapeutic targets based on these cell death interactions can aid in CVD prevention and treatment.
  • Targeting these cell death pathways holds promise for reducing CVD mortality and enhancing quality of life.
Keywords:
apoptosisautophagycardiovascular disease (CVD)crosstalkpyroptosis

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