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Prognostic Significance of Percutaneous Coronary Intervention for First Acute Myocardial Infarction with Heart

Zichao Cheng1, Yuchen Shi1, Hongyu Peng1

  • 1Center for Coronary Artery Disease (CCAD), Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University,and Beijing Institute of Heart,Lung and Blood Vessel Diseases, Beijing, China.

Cardiology Research and Practice
|November 17, 2022
PubMed

Insights

Heart failure occurred in 15.9% of patients five years after percutaneous coronary intervention for acute myocardial infarction. Age, peak troponin I, and left ventricular end-diastolic dimension were risk factors, while left ventricular ejection fraction was protective.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Interventional Cardiology

Background:

  • Acute myocardial infarction (AMI) is a leading cause of heart failure.
  • Percutaneous coronary intervention (PCI) is a primary treatment for AMI.
  • Long-term outcomes, including heart failure development post-PCI, require further investigation.

Purpose of the Study:

  • To determine the incidence of heart failure 5 years after PCI for first AMI.
  • To identify clinical factors influencing heart failure development in these patients.

Main Methods:

  • A cohort of 609 patients treated with PCI for first AMI was followed for 5 years.
  • Echocardiographic data was collected to assess left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension (LVEDD).
  • Logistic regression and ROC analyses identified predictors of heart failure (defined as LVEF < 50%).

Main Results:

  • The incidence of heart failure at 5 years post-PCI was 15.9% (97/609 patients).
  • Significant predictors of heart failure included older age (aOR 1.008), higher peak troponin I (aOR 1.020), and increased LVEDD (aOR 1.136).
  • Lower LVEF during admission (aOR 0.908) was a protective factor against heart failure development.

Conclusions:

  • Heart failure affects a significant proportion of patients within 5 years of PCI for AMI.
  • Age, peak troponin I, LVEDD, and admission LVEF are crucial factors in predicting long-term heart failure risk.
  • These findings highlight the importance of early risk stratification and management post-PCI.
Abstract

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