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Updated: Aug 21, 2025
Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Histopathological Features of Helicobacter pylori Infection in Gastric Mucosa
Yang-Kun Wang1, Chun Li2, Yong-Mei Zhou1
1Department of Pathology, Foresea Life Insurance Guangzhou General Hospital, Guangzhou, 511300, People's Republic of China.
Objective:
To investigate the histopathological characteristics of Helicobacter pylori (Hp) infection in the gastric mucosa in the process from occurrence to intraepithelial neoplasia.
Methods:
Specimens obtained from the endoscopic biopsy and endoscopic submucosal dissection of 2457 cases of gastric Hp infection were observed and assessed in detail using histology and immunohistochemistry techniques. The condition was divided according to the histopathological characteristics of gastric mucosal damage caused by Hp infection. The histopathological characteristics and immunophenotype of each stage were subsequently elucidated.
Results:
Helicobacter pylori is initially implanted in the mucus layer covered by the epithelium on the surface of the gastric mucosa. It then selectively adheres to the cytoplasm of the surface mucus cells, which makes the oval and spherical particles containing mucus that is wrapped by the bounded membrane in the cytoplasm on the nucleus of the surface mucus cells disappear, while the cytoplasm undergoes spiderweb-like vacuolar degeneration. This leads to the proliferation and transformation of the surface mucous cells before developing into intraepithelial neoplasia. In the process of histomorphology, mucosal ulcers, mucosal lymphoid tissue proliferation, gland atrophy, intestinal epithelial metaplasia, mucosa-associated lymphoid tissue lymphoma, and adenocarcinoma may occur. In this study, the condition was divided into five stages according to the histopathological characteristics of gastric mucosal damage caused by Hp infection, as well as the degree of gastric mucosal damage and involvement depth as follows: the mucus infection stage, the surface epithelial cell infection stage, the lamina propria lesion stage, the mucosal atrophy stage, and the intraepithelial neoplasia stage.
Conclusion:
Understanding the histopathological characteristics of gastric Hp infection in terms of its occurrence and development into intraepithelial neoplasia is conducive to the precise treatment and tracking of malignant cell transformation, and is of great significance in controlling the occurrence and development of gastric cancer.
Insights
This study details the histopathological progression of Helicobacter pylori (H. pylori) infection in gastric mucosa, from initial colonization to intraepithelial neoplasia. Understanding these stages aids in precise treatment and tracking of gastric cancer development.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Helicobacter pylori (Hp) infection is a major risk factor for gastric diseases.
- Understanding the histopathological evolution of Hp infection is crucial for early detection and management of gastric cancer.
Purpose of the Study:
- To investigate the histopathological characteristics of Hp infection in gastric mucosa.
- To elucidate the progression from Hp infection to intraepithelial neoplasia.
Main Methods:
- Histology and immunohistochemistry were used to analyze 2457 gastric Hp infection cases.
- Specimens from endoscopic biopsy and submucosal dissection were examined.
- Gastric mucosal damage was staged based on Hp infection characteristics.
Main Results:
- Hp initially infects surface mucus cells, causing cytoplasmic vacuolar degeneration.
- Progression involves mucosal ulcers, lymphoid proliferation, gland atrophy, and intestinal metaplasia.
- Five distinct stages were identified: mucus infection, epithelial cell infection, lamina propria lesion, mucosal atrophy, and intraepithelial neoplasia.
Conclusions:
- Detailed understanding of Hp-induced histopathological changes is vital.
- This knowledge supports precise treatment and monitoring of malignant transformation.
- Crucial for controlling the development of gastric cancer.
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