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COVID-19 Vaccination reduced pneumonia severity
Noriaki Wada1, Yi Li2, Takuya Hino3
1Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
European Journal of Radiology Open
|November 17, 2022
Summary
COVID-19 vaccination and boosters significantly reduce the severity of COVID-19 pneumonia on CT scans. Vaccinated individuals, including those with boosters, showed milder pneumonia compared to unvaccinated individuals during the Delta and Omicron variants periods.
Area of Science:
- Radiology
- Infectious Diseases
- Immunology
Background:
- COVID-19 pneumonia presents a significant public health challenge.
- The Delta and Omicron variants have demonstrated distinct epidemiological characteristics.
- Understanding the impact of vaccination on disease severity is crucial for public health strategies.
Purpose of the Study:
- To evaluate the effect of COVID-19 vaccination and booster doses on the severity of COVID-19 pneumonia as assessed by CT scans.
- To compare radiological findings in vaccinated versus unvaccinated patients during the Delta and Omicron variant surges.
Main Methods:
- A retrospective study of 303 patients diagnosed with COVID-19 between July 2021 and February 2022.
- Pneumonia severity was quantified using a 6-point Pneumonia Score on CT scans obtained within 6 weeks of diagnosis.
- Analysis included demographic data, clinical information, and vaccination status (unvaccinated, fully vaccinated, boosted/additionally vaccinated).
Main Results:
- A high interobserver agreement (weighted kappa score = 0.875) was achieved for the Pneumonia Score.
- Patients receiving booster/additional vaccinations were older and had more comorbidities.
- Significantly lower Pneumonia Scores were observed in boosted (median 2) and fully vaccinated (median 3) groups compared to unvaccinated individuals (median 4).
Conclusions:
- COVID-19 vaccination, with or without boosters, is associated with reduced severity of COVID-19 pneumonia on CT scans.
- Radiological evidence supports the protective efficacy of COVID-19 vaccines against severe pneumonia during the Delta and Omicron variant periods.
Keywords:
COVID-19COVID-19, coronavirus disease 2019CTDAD, diffuse alveolar damageGGO, ground-glass opacityLungOP, organizing pneumoniaPneumoniaRT-PCR, reverse transcription-polymerase chain reactionSARS-CoV-2, severe acute respiratory syndrome coronavirus 2VaccinationmRNA, messenger ribonucleic acidMore Related Videos
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