A time-restricted feeding intervention in children and adolescents with obesity: The TRansForm study protocol

Area of Science:

• Pediatric Endocrinology
• Metabolic Health
• Chronobiology

Background:

• Childhood obesity is a significant public health concern, tracking into adulthood and increasing risk for metabolic disorders.
• Time-restricted feeding (TRF) is a potential obesity treatment strategy, but its effects in pediatric populations are unknown.
• Understanding the impact of TRF on children's health is crucial for developing effective interventions.

Purpose of the Study:

• To determine the short- and long-term safety and effectiveness of time-restricted feeding (TRF) in children and adolescents with obesity.
• To investigate potential mechanisms, including circadian rhythm and gut microbiota, mediating the response to TRF.
• To provide evidence for TRF as a viable obesity management strategy in pediatric populations.

Main Methods:

• A randomized-controlled parallel-group clinical study involving children and adolescents (8-18 years) with obesity.
• Participants will be assigned to either a TRF group or a control group (no time restrictions) for 2 months.
• Measurements include anthropometric (BMI, body composition), metabolic parameters, circadian rhythm indicators, and gut microbiota analysis, with long-term follow-up.

Main Results:

• This section is to be filled upon study completion.
• Data analysis will focus on changes in weight, body composition, and metabolic markers.
• Exploration of correlations between TRF, circadian rhythm, and gut microbiome shifts will be conducted.

Conclusions:

• This study will establish the safety and efficacy of TRF for pediatric obesity.
• Long-term effects and underlying biological mechanisms of TRF will be elucidated.
• Findings may support the integration of TRF into clinical practice for managing childhood obesity.