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Related Concept Videos

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Related Experiment Video

Updated: Aug 21, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
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Grape polyphenols decrease circulating branched chain amino acids in overfed adults.

Simona Bartova1, Francisco Madrid-Gambin2, Luis Fernández2,3

  • 1Nestlé Research, EPFL Innovation Park, Lausanne, Switzerland.

Frontiers in Nutrition
|November 17, 2022
PubMed
Summary

Grape polyphenol extract supplementation helped protect against metabolic changes caused by overfeeding in adults. This dietary intervention counterbalanced harmful increases in branched-chain amino acids (BCAAs) during the study.

Keywords:
NMRbranched chain amino acidsgrape polyphenolshuman trialsmetabolismmetabolomicsobesityoverfeeding

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Area of Science:

  • Metabolomics
  • Nutrition Science
  • Clinical Trials

Background:

  • Dietary polyphenols are linked to health benefits, including obesity prevention.
  • Overfeeding induces weight gain, fat mass, and insulin resistance, serving as a model for obesity complications.
  • Understanding metabolic responses to overfeeding is crucial for developing preventative strategies.

Purpose of the Study:

  • To investigate the impact of grape polyphenol extract on the plasma metabolome during a controlled overfeeding intervention.
  • To assess the protective effects of polyphenol supplementation against metabolic disturbances induced by overfeeding in adults.

Main Methods:

  • Two randomized controlled clinical trials (male and female participants) were conducted.
  • Participants underwent a 31-day overfeeding period (50% excess energy intake).
  • Nuclear magnetic resonance (NMR)-based metabolomics analyzed plasma samples for metabolic changes.

Main Results:

  • Overfeeding altered plasma levels of key metabolites, including branched-chain amino acids (BCAAs) and glucose.
  • Grape polyphenol supplementation counteracted the overfeeding-induced increase in BCAAs.
  • These findings were consistent across both male and female study cohorts.

Conclusions:

  • A 1-month administration of grape polyphenol-rich extract demonstrated a protective metabolic effect against overfeeding in adults.
  • Polyphenol supplementation may mitigate adverse metabolic consequences associated with overnutrition.
  • This suggests a potential role for grape polyphenols in managing metabolic health.