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Trends in metabolic signaling pathways of tumor drug resistance: A scientometric analysis

Ruiqi Jiang1,2, Mingnan Cao1, Shenghui Mei1,2

  • 1Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Frontiers in Oncology
|November 17, 2022
PubMed
Abstract

Insights

This study analyzes research on tumor metabolism and drug resistance, revealing key trends and emerging hotspots like the tumor microenvironment. Understanding these metabolic pathways is crucial for overcoming chemotherapy resistance in cancer therapy.

Area of Science:

  • Oncology
  • Cancer Research
  • Metabolic Signaling

Background:

  • Chemotherapy resistance remains a significant challenge in cancer treatment.
  • Tumor metabolism significantly influences the efficacy of chemotherapeutic drugs.
  • Targeting tumor energetics shows promise in preclinical cancer research.

Purpose of the Study:

  • To summarize the knowledge structure of research on metabolic signaling pathways in tumor drug resistance.
  • To identify emerging trends and potential research hotspots in this field.

Main Methods:

  • Scientometric analysis of 2,537 publications from 1992-2022 using Web of Science Core Collection.
  • Utilized CiteSpace and VOSviewer software for data analysis.
  • Keywords occurrence and burst detection were employed to identify research topics and trends.

Main Results:

  • The USA leads in contributions, with the University of Texas MD Anderson Cancer Center as the leading institution.
  • Key research areas include apoptosis, resistance mechanisms, cancer stem cells, oxidative stress, inflammation, and autophagy.
  • Emerging hotspots include "tumor microenvironment," "invasion," and "target."

Conclusions:

  • Research on tumor metabolic reprogramming and drug resistance is rapidly advancing.
  • This study provides a comprehensive overview of the field's development landscape.
  • Identified trends and hotspots offer insights into future research opportunities.
Keywords:
drug resistancemetabolismscientometricssignaling pathwaystumor

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