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ATRA-induced bradycardia in a case of acute promyelocytic leukemia: A case report

Santosh Govind Rathod1, Afaq Ahmad Khan1, Sajad Ahmed Geelani1

  • 1Department of Clinical Hematology, SKIMS, Srinagar, Jammu and Kashmir, India.

Journal of Family Medicine and Primary Care
|November 17, 2022
PubMed

A 45-year-old female, a new case of acute promyelocytic leukemia (APL), received induction chemotherapy containing all-trans retinoic acid (ATRA) and idarubicin. On the sixth day of therapy, she developed sinus bradycardia and differentiation syndrome (DS). Electrolytes and cardiac imaging were normal. The patient achieved normal sinus rhythm after ATRA was withheld, and DS was treated.

Keywords:
Acute Promyelocytic LeukemiaPML–RARαall-trans retinoic acidbradycardiadifferentiation syndrome (DS)idarubicin

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