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Invasive fungal sinusitis-A neglected but important association with COVID 19 infection and a ticking bomb

Viral B Patel1, Radhika H Pandya1, Shreya D Patel1

  • 1Department of Radiodiagnosis, PS Medical College and Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, India.

Journal of Family Medicine and Primary Care
|November 17, 2022
PubMed

Insights

Fungal coinfections in COVID-19 patients are often missed. Early detection of invasive mycoses like aspergillosis and mucormycosis is crucial for severe and immunocompromised cases.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Severe acute respiratory syndrome (SARS) and influenza data analysis suggests fungal coinfections are underdiagnosed in global SARS-CoV-2 cases.
  • Coronavirus disease 2019 (COVID-19) patients, particularly severe or immunocompromised individuals, are at higher risk for invasive fungal infections.

Observation:

  • Two cases of invasive fungal infections in COVID-19 patients are presented.
  • One case involved aspergillosis of the unilateral orbit and maxilla.
  • The second case featured mucormycosis affecting the paranasal sinuses and bilateral orbits.

Findings:

  • Fungal coinfections, including aspergillosis and mucormycosis, are likely underdiagnosed in COVID-19 patients.
  • Invasive mycoses pose a significant threat to severely ill and immunocompromised COVID-19 patients.

Implications:

  • Emphasizes the need for early detection and prompt treatment of invasive fungal infections in COVID-19 patients.
  • Highlights the importance of considering fungal coinfections in the differential diagnosis for severe COVID-19 cases.
  • Suggests that improved diagnostic strategies are needed to identify these opportunistic infections effectively.
Keywords:
AspergillosisCOVID-19 infectionRT-PCR (reverse transcriptase-polymerase chain reaction)SARS (severe acute respiratory syndrome)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)influenzaorbitparanasal sinusesrhizomucormycosis

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