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Safe and Effective Lip Enhancement with VYC-15L in Chinese Adults
Dong Li1, Zhanwei Gao2, Jiaming Sun3
1Peking University Third Hospital, Beijing, People's Republic of China.
Background:
Hyaluronic acid (HA) soft tissue fillers are used to restore volume loss to the lips and perioral area.
Objective:
Evaluate the safety and effectiveness of the HA filler Juvéderm® Volbella® (VYC-15L) for lip enhancement in Chinese adults.
Methods & Materials:
In this multicenter, evaluator-blind study, subjects seeking lip enhancement were randomized 3:1 to VYC-15L or no-treatment control group (with optional treatment delayed by 3 months). Effectiveness endpoints included 1-point improvement on the 5-point Lip Fullness Scale (LFS) assessed by evaluating investigators (EIs) and subjects, and overall volume of lips and change in lip surface area measured from 3-dimensional images. Safety assessments included procedural pain, injection site reactions (ISRs), and adverse events (AEs).
Results:
The modified intention-to-treat population included 163 subjects (median age, 34 years; 96.9% female). More VYC-15L-treated subjects had a 1-point reduction in EI-reported LFS score at month 3 versus untreated controls (84.7% vs 0%; p < 0.0001), and 65% of the treated subjects self-reported a 1-point LFS improvement at month 3. Procedural pain during injection was mild. The most common ISRs were swelling, tenderness to touch, and firmness. One treatment-related serious AE (injection site compression arterial ischemia) resolved in 16 days.
Conclusion:
VYC-15L treatment was superior to no treatment at 3 months and was well tolerated by subjects.
Clinical Trial Registration Number:
NCT03519204.
