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A silk-based self-adaptive flexible opto-electro neural probe.

Yu Zhou1,2, Chi Gu1,2, Jizhi Liang1,2

  • 1State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, 200050 Shanghai, China.

Microsystems & Nanoengineering
|November 17, 2022
PubMed
Summary

Researchers developed a novel Silk-Optrode probe combining silk optical fibers and microelectrodes for precise brain circuit analysis. This flexible probe enables simultaneous optogenetic stimulation and neural recording with improved biocompatibility and implantation accuracy.

Keywords:
BiosensorsElectrical and electronic engineering

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Area of Science:

  • Neuroscience
  • Biomaterials Engineering
  • Neural Engineering

Background:

  • Optogenetics and electrophysiology are crucial for studying neural circuits.
  • Flexible neural probes are needed for chronic recording but face implantation challenges.
  • Existing probes lack mechanical adaptability for precise, minimally invasive brain insertion.

Purpose of the Study:

  • To develop a hybrid neural probe for simultaneous optogenetic stimulation and multichannel electrophysiological recording.
  • To enhance probe biocompatibility and implantation accuracy for chronic neural interface applications.
  • To overcome the mechanical mismatch between rigid probes and soft brain tissue.

Main Methods:

  • Fabrication of a hybrid probe (Silk-Optrode) using a silk protein optical fiber and flexible microelectrode arrays.
  • Utilizing silk's tunable mechanical properties via hydration for adaptive implantation.
  • Synchronized optogenetic stimulation and 128-channel neural recording in freely behaving animals.

Main Results:

  • The Silk-Optrode demonstrated accurate brain insertion and stable chronic recording (2 months).
  • Probes showed high-yield, well-isolated single-unit recordings with low optical loss during stimulation.
  • Reduced glial response and tissue lesions compared to previous probe types.

Conclusions:

  • The Silk-Optrode offers a promising solution for advanced neural interface applications.
  • Silk's unique properties enable adaptive mechanical behavior for improved implantation and biocompatibility.
  • This technology facilitates detailed investigation of neural circuits in behaving animals.