Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Association between genetic polymorphism of tumor necrosis factor and chronic severe hepatitis B in patients].

Zhonghua yi xue za zhi·2007
Same author

In vivo translational inaccuracy in Escherichia coli: missense reporting using extremely low activity mutants of Vibrio harveyi luciferase.

Biochemistry·2007
Same author

[Construction of recombinant adenovirus vector expressing extracellular domain of TbetaR-II-RANTES fusion gene and its anti-tumor effects].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2007
Same author

[Characteristics, evolution and variation of M genes of human avian H5N1 strains in Guangdong].

Bing du xue bao = Chinese journal of virology·2007
Same author

Dynamic changes in microbial activity and community structure during biodegradation of petroleum compounds: a laboratory experiment.

Journal of environmental sciences (China)·2007
Same author

Differences in optical transport properties between human meridian and non-meridian.

The American journal of Chinese medicine·2007
Same journal

Striatal functional connectivity alterations in mild cognitive impairment subtypes defined by CSF A/T biomarkers.

Frontiers in aging neuroscience·2026
Same journal

State sensitivity and five-year longitudinal stability of resting-state EEG biomarker candidates in healthy adults.

Frontiers in aging neuroscience·2026
Same journal

FLOT1 and EEF1D: ac4C-related genes bridging Alzheimer's disease and sleep deprivation.

Frontiers in aging neuroscience·2026
Same journal

Deciphering MMRN1 diagnostic and therapeutic implications in the substantia nigra of Parkinson's disease patients via integrative bioinformatic analysis and multi-omics studies.

Frontiers in aging neuroscience·2026
Same journal

Biomarkers, diagnosis, and the meaning of disease: evaluating competing frameworks for Alzheimer's disease classification.

Frontiers in aging neuroscience·2026
Same journal

Correction: Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders.

Frontiers in aging neuroscience·2026
See all related articles

Related Experiment Video

Updated: Aug 21, 2025

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

48.3K

Lesions causing post-stroke spasticity localize to a common brain network.

Yin Qin1,2, Shuting Qiu1,3, Xiaoying Liu1,2

  • 1Department of Rehabilitation Medicine, The 900th Hospital of Joint Logistic Support Force, People's Liberation Army (PLA), Fuzhou, China.

Frontiers in Aging Neuroscience
|November 17, 2022
PubMed
Summary
This summary is machine-generated.

Post-stroke spasticity (PSS) lesions connect to a common brain network involving the bilateral putamen and globus pallidus. These key regions are linked to spasticity severity, offering potential targets for early intervention.

Keywords:
functional connectivitylesion network mappinglesionspost-stroke spasticityresting-state networks

More Related Videos

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

949
Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
10:15

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

18.0K

Related Experiment Videos

Last Updated: Aug 21, 2025

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

48.3K
Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

949
Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
10:15

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

18.0K

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Clinical interventions for post-stroke spasticity (PSS) show limited efficacy.
  • The neuroanatomical basis of PSS is unclear due to heterogeneous lesion locations.

Purpose of the Study:

  • Investigate if PSS-causing lesions localize to a common brain network.
  • Identify key brain network nodes associated with PSS.

Main Methods:

  • Utilized lesion network mapping on 32 PSS cases and the Human Connectome dataset (n=1,000).
  • Assessed functional connectivity, reproducibility via split-half analysis, and specificity against non-spastic controls (n=29).
  • Employed conjunction and correlation analyses to identify and explore PSS-specific regions.

Main Results:

  • Lesions in 93% of PSS patients (29/32) showed functional connectivity with the bilateral putamen and globus pallidus.
  • Connectivity patterns were repeatable and specific to PSS compared to non-spastic controls.
  • Functional connectivity strength with the putamen and globus pallidus positively correlated with spasticity severity.

Conclusions:

  • Identified a common functional connectivity network for PSS lesions, centered on the bilateral putamen and globus pallidus.
  • The putamen and globus pallidus are potential key regions implicated in PSS.
  • Findings aid in early identification of high-risk patients and suggest PSS-specific brain stimulation targets.