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Linezolid induced psychosis and hallucination: Case report and literature review

Hamza Maqsood1, Salman Sajjad1, Saba Aslam1

  • 1Nishtar Medical University and Hospital, Multan, Pakistan.

Annals of Medicine and Surgery (2012)
|November 17, 2022
PubMed
Abstract

Insights

This case report highlights a rare instance of linezolid-induced psychosis and hallucinations. Promptly stopping the antibiotic led to the patient's successful recovery, emphasizing the need for careful monitoring.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Infectious Diseases

Background:

  • Antibiotics can cause neuropsychiatric adverse drug reactions (ADRs), including psychosis and delirium.
  • The prevalence of psychosis ADRs for antibiotics varies between 0.3% and 3.8%.

Observation:

  • A 52-year-old male patient developed altered consciousness and hallucinations during linezolid treatment for severe burns.
  • Clinical and laboratory findings supported a diagnosis of linezolid-induced psychosis and hallucination, with a Naranjo score of +8.

Findings:

  • Linezolid, an antibiotic, can rarely lead to toxic blood levels causing neuropsychiatric symptoms.
  • Psychosis and hallucinations induced by linezolid are reversible upon drug discontinuation.

Implications:

  • Physicians should monitor linezolid blood levels to prevent serious neuropsychiatric adverse effects.
  • Early recognition and cessation of linezolid are crucial for managing psychosis and hallucinations in patients.
Keywords:
Adverse drug reactionAntibioticConfusionHallucinationsInfectionLinezolidNeuropsychiatricPsychosis

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