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Monocyte response after colorectal surgery: A prospective cohort study
Pim P Edomskis1, Willem A Dik2,1, Cloë L Sparreboom3
1Laboratory Medical Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
Frontiers in Immunology
|November 17, 2022
Summary
Post-colorectal surgery, immune cell redistribution and monocyte subset changes occur rapidly. Monocytes show a mixed activation and de-activation profile, offering insights into post-operative stress responses.
Area of Science:
- Immunology
- Surgical Oncology
- Cell Biology
Background:
- Colorectal tumor resection is a standard treatment.
- Understanding post-operative inflammatory responses is crucial for complication identification.
- Circulating monocytes are key leukocyte responders to surgical trauma.
Purpose of the Study:
- To analyze monocyte subset kinetics and phenotypes following colorectal tumor resection.
- To establish reference parameters for post-operative immune changes.
Main Methods:
- Prospective cohort study of 50 patients undergoing colorectal tumor resection.
- Flow cytometry analysis of blood samples collected pre-surgery and up to postoperative day 3.
- Quantification of leukocyte subtypes and monocyte subset activation markers.
Main Results:
- Leukocyte and monocyte subset changes peaked on postoperative day 1, returning to baseline by day 3.
- Classical and intermediate monocytes showed significant immunophenotypic alterations.
- Upregulation of CD64 and CD62L, downregulation of HLA-DR and CD54, and increased CD163 and CD206 expression were observed.
Conclusions:
- Colorectal cancer surgery induces rapid immune cell redistribution.
- Monocyte immunophenotypic changes suggest a combined cellular activation and de-activation response.
- These findings provide insights into the acute immune response to surgical stress.
