Related Experiment Video

Updated: Aug 20, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.9K

[Melanoma microenvironment-impact of modern therapies]

Judith Sirokay1, Cornelia Mauch2

  • 1Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum Bonn, Gebäude 11, Venusberg-Campus 1, 53127, Bonn, Deutschland. judith.sirokay@ukbonn.de.

Dermatologie (Heidelberg, Germany)
|November 17, 2022
PubMed
Abstract

Insights

Despite initial success, many advanced melanoma patients develop metastatic disease. Targeting the tumor microenvironment offers innovative strategies to improve melanoma treatment efficacy.

Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Context:

  • Advanced melanoma presents a significant challenge due to metastatic progression.
  • Current therapies show initial success but often fail to prevent disease spread.

Purpose:

  • To provide an overview of the melanoma tumor microenvironment.
  • To discuss approved therapies and novel strategies for advanced melanoma treatment.

Summary:

  • The tumor microenvironment (TME) is crucial in melanoma progression and response to therapy.
  • Components and interactions within the TME significantly influence treatment outcomes.
  • Current research focuses on understanding these interactions to develop better therapeutic approaches.

Impact:

  • Innovative strategies targeting an immunosuppressive TME hold promise for improving therapeutic efficacy.
  • Modulating the tumor microenvironment could overcome resistance to existing melanoma treatments.
  • This review aids in developing more effective treatment paradigms for advanced melanoma.
Keywords:
ImmunotherapyNew therapeutic strategiesSystemic therapiesTargeted therapyTherapeutic response

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.5K
Author Spotlight: Recreating Melanoma Complexity with Patient-Derived Organoids for Immunotherapy Evaluation05:33

Author Spotlight: Recreating Melanoma Complexity with Patient-Derived Organoids for Immunotherapy Evaluation

Published on: September 6, 2024

1.7K

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.4K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
631
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K