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Related Experiment Video

Updated: Aug 20, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
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Posture-related changes in sympathetic baroreflex sensitivity during normal pregnancy.

Sarah L Hissen1,2, Ryosuke Takeda1,2, Jeung-Ki Yoo1,2

  • 1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, 7232 Greenville Avenue, Dallas, TX, 75231, USA.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|November 17, 2022
PubMed
Summary

Sympathetic baroreflex sensitivity during pregnancy is posture-dependent. Supine sensitivity increases in early pregnancy, while tilt sensitivity is blunted in both early and late pregnancy compared to supine.

Keywords:
Autonomic functionHead-up tiltMicroneurographyMuscle sympathetic nerve activityUncomplicated pregnancy

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Area of Science:

  • Cardiovascular physiology
  • Autonomic nervous system regulation
  • Reproductive health

Background:

  • Normal pregnancy involves significant cardiovascular autonomic control adjustments.
  • Previous studies on sympathetic baroreflex sensitivity during human pregnancy yielded inconclusive longitudinal data.
  • The impact of body posture on longitudinal changes in sympathetic baroreflex sensitivity during pregnancy remains unclear.

Purpose of the Study:

  • To investigate the longitudinal impact of body posture on sympathetic baroreflex sensitivity throughout normal pregnancy.
  • To compare sympathetic baroreflex sensitivity in early pregnancy, late pregnancy, and postpartum across different body positions.

Main Methods:

  • Assessed spontaneous sympathetic baroreflex sensitivity in 24 pregnant women.
  • Measurements were taken in early pregnancy (6-11 weeks), late pregnancy (32-36 weeks), and postpartum (6-10 weeks).
  • Evaluated sensitivity in supine, 30° head-up tilt, and 60° head-up tilt positions.

Main Results:

  • Supine sympathetic baroreflex sensitivity was augmented in early pregnancy compared to postpartum.
  • Sympathetic baroreflex sensitivity during head-up tilt (30° and 60°) did not differ significantly across pregnancy phases.
  • Compared to the supine position, 60° head-up tilt significantly blunted sympathetic baroreflex sensitivity in both early and late pregnancy, but not postpartum.

Conclusions:

  • Longitudinal changes in sympathetic baroreflex sensitivity during pregnancy are significantly influenced by body posture.
  • These findings provide crucial insights into normal blood pressure regulation during pregnancy.
  • Establishes a baseline for future research on pregnancy complications and cardiovascular risks.