Related Experiment Video
Updated: Aug 20, 2025

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Windows into stress: a glimpse at emerging roles for CRHPVN neurons
Neilen P Rasiah1, Spencer P Loewen1, Jaideep S Bains1
1Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Abstract:
The corticotropin-releasing hormone cells in the paraventricular nucleus of the hypothalamus (CRHPVN) control the slow endocrine response to stress. The synapses on these cells are exquisitely sensitive to acute stress, leveraging local signals to leave a lasting imprint on this system. Additionally, recent work indicates that these cells also play key roles in the control of distinct stress and survival behaviors. Here we review these observations and provide a perspective on the role of CRHPVN neurons as integrative and malleable hubs for behavioral, physiological, and endocrine responses to stress.
Related Concept Videos
Hypothalamic-Pituitary Axis
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Stress Response System
Alarm stage
In the alarm stage, the body's...
The Sympathetic Nervous System
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Psychological Responses to Stress

