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Cyclodextrin-based dermatological formulations: Dermopharmaceutical and cosmetic applications
Laura Ferreira1, Filipa Mascarenhas-Melo1, Sofia Rabaça2
1Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal.
Cyclodextrins (CDs) enhance active ingredient delivery in cosmetics and derms. These versatile carriers improve solubility, stability, and skin permeation for better formulations and treatments.
Area of Science:
- Dermopharmaceutics and Cosmetic Science
- Drug Delivery Systems
- Supramolecular Chemistry
Background:
- Advancements in delivery systems enhance skin permeation for active ingredients.
- Cyclodextrins (CDs), cyclic oligosaccharides, form inclusion complexes with active molecules.
- CDs improve physicochemical properties and offer biocompatible delivery in topical formulations.
Purpose of the Study:
- To highlight the advantages of using cyclodextrins (CDs) in dermopharmaceutical and cosmetic applications.
- To emphasize the role of CDs in enhancing skin permeation and active ingredient delivery.
- To showcase the potential of CDs in treating skin diseases and improving cosmetic products.
Main Methods:
- Review of literature on cyclodextrin applications in topical formulations.
- Analysis of the impact of CDs on the solubility and stability of active ingredients.
- Evaluation of the skin permeation enhancement and vectorization capabilities of CDs.
Main Results:
- CDs significantly improve the apparent solubility and stability of active ingredients.
- CDs facilitate controlled release and enhance the permeation of active molecules through the skin.
- CDs can mask unpleasant odors and provide a biocompatible delivery system.
Conclusions:
- Cyclodextrins are versatile carriers with significant promise for dermopharmaceutical and cosmetic applications.
- CDs offer improved efficacy and patient compliance in the treatment of skin conditions.
- The use of CDs can lead to innovative and enhanced cosmetic formulations.
