Related Experiment Video
Updated: Aug 20, 2025

Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice
Published on: July 2, 2018
A case of acute myocardial infarction in paced rhythm. Utility of the Barcelona algorithm
Ranganathan R Ramanathan1, Vickram Vignesh Rangaswamy2, T Nanda Kumar3
1Consultant Interventional Cardiologist, Aram Medical Foundation, Pollachi, Coimbatore, India.
Insights
A novel algorithm aids in diagnosing acute myocardial infarction in patients with pacemakers. The Barcelona algorithm successfully identified myocardial infarction in a patient with right-ventricular pacing, challenging traditional criteria.
Area of Science:
- Cardiology
- Electrocardiography
Background:
- Standard Sgarbossa and modified Smith criteria are used for diagnosing myocardial infarction (MI) in patients with left bundle branch block (LBBB).
- Diagnosing MI in patients with pacemaker-induced QRS changes, such as right-ventricular pacing, presents unique electrocardiographic challenges.
- Atypical chest pain in patients with pacemakers requires careful diagnostic evaluation.
Observation:
- A 70-year-old male with a pacemaker presented with atypical chest pain.
- Initial ECGs did not meet Sgarbossa or modified Smith criteria for MI.
- The recently developed Barcelona algorithm was applied to the patient's ECG.
Findings:
- The Barcelona algorithm identified electrocardiographic criteria for acute myocardial infarction.
- Specifically, lead V6 showed a low voltage QRS complex and ST depression, meeting the Barcelona criteria.
- This diagnosis led to primary angioplasty for in-stent restenosis of the left anterior descending coronary artery.
Implications:
- This case is the first to report the use of the Barcelona algorithm for diagnosing acute coronary syndrome in a right-ventricular paced rhythm.
- The findings suggest the Barcelona algorithm may be valuable in diagnosing MI in challenging ECG presentations, including those with pacemakers.
- Further research is warranted to validate the Barcelona algorithm's utility in pacemaker-dependent rhythms for acute coronary syndrome diagnosis.
Abstract:
We describe the case of a 70-year-old man with a pacemaker implant who presented to us with atypical chest pain. His admission ECG did not satisfy the criteria for myocardial infarction according to standard Sgarbossa criteria, and Smith modified Sgarbossa criteria. However, we applied the recently developed Barcelona algorithm, which is used to diagnose acute myocardial infarction in the presence of intrinsic left bundle branch block.Electrocardiographic criteria for an acute myocardial infarction were met. Lead V6 displayed a low voltage QRS complex (3 mm) with 1 mm ST depression, satisfying the Barcelona criteria for acute myocardial infarction. He underwent primary angioplasty for critical in-stent restenosis of the left anterior descending coronary artery. This is the first case report, to the best of our knowledge, where Barcelona algorithm has been used to diagnose acute coronary syndrome in right-ventricular paced rhythm.
Related Concept Videos
Pulse rhythm
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Correlation between ECG and Cardiac Cycle
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
Cardiopulmonary Resuscitation IV: Pharmacological Management
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Dysrhythmias V: Evaluating Dysrhythmias

