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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Related Experiment Video

Updated: Aug 20, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

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Recent progress in epigenetics of obesity.

Feng-Yao Wu1, Rui-Xing Yin2,3

  • 1Department of Comprehensive Internal Medicine, Affiliated Infectious Disease Hospital of Nanning (The Fourth People's Hospital of Nanning), Guangxi Medical University, No. 1 Erli, Changgang Road, Nanning, 530023, Guangxi, People's Republic of China.

Diabetology & Metabolic Syndrome
|November 18, 2022
PubMed
Summary

Epigenetics, including DNA methylation, plays a crucial role in obesity development by mediating gene-environment interactions. Understanding these epigenetic factors can help predict obesity risk and inform targeted prevention strategies.

Keywords:
DNA methylationEpigeneticsHistone modificationObesitymiRNA

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Area of Science:

  • Genetics and Epigenetics
  • Public Health
  • Metabolic Diseases

Background:

  • Obesity is a major global health issue, affecting over 2.2 billion people worldwide.
  • Genetic factors only partially explain obesity, highlighting the need to explore other regulatory mechanisms.
  • Epigenetics, encompassing DNA methylation and histone modifications, is increasingly recognized for its role in gene-environment interactions relevant to obesity.

Purpose of the Study:

  • To investigate the role of epigenetics in the development of obesity and its associated metabolic complications.
  • To explore how epigenetic mechanisms regulate gene-environment interactions in obesity.
  • To identify potential epigenetic biomarkers for obesity risk prediction and targeted interventions.

Main Methods:

  • Review of epigenome-wide association studies (EWAS) and genome-wide histone modification studies.
  • Analysis of epigenetic data from various biological specimens including blood, adipose tissue, skeletal muscle, placenta, and saliva.
  • Examination of differential gene expression before and after obesity interventions.

Main Results:

  • Preliminary evidence from animal and human studies supports the significant influence of epigenetics on obesity.
  • Multiple candidate genes and biological markers associated with obesity have been identified through epigenetic studies.
  • Differential gene expression patterns related to obesity have been observed across diverse populations and biological samples.

Conclusions:

  • Epigenetic mechanisms are key regulators in the complex etiology of obesity.
  • Epigenetic insights can improve the understanding of obesity and its comorbidities.
  • Identifying epigenetic markers may enable early obesity risk prediction and facilitate targeted prevention and treatment strategies.