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Published on: October 3, 2018
Disseminated fusarium infection after allogeneic hematopoietic stem cell transplantation after CART: A case report
Hairong Fei1, Xiaodan Liu, Lingjie Sun
1Department of Hematology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Background:
Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function.
Methods:
A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor-modified T cells treatment.
Results:
During transplantation, disseminated Fusarium infection occurred, involving the skin, liver, spleen and central nervous system, and the patient eventually died.
Conclusions:
Early identification of Fusarium infection based on the characteristic rash and timely antifungal treatment can improve the cure rate.
