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Chordin-Like 2: A Possible Therapeutic Target for Gastric Cancer by Affecting Cell Cycle and Proliferation

Yuan Zhou1, Guangxin Cao2, Zhifeng Guan3

  • 1Department of Hepatobiliary Surgery, Tumor Hospital Affiliated to Nantong University, Nantong Tumor Hospital, Nantong, China.

Journal of Oncology
|November 18, 2022
PubMed
Abstract

Insights

Chordin-like 2 (CHRDL2) is upregulated in gastric cancer, correlating with poor prognosis and immune evasion. Lowering CHRDL2 may inhibit cancer progression by impacting cell cycle and apoptosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Gastric cancer remains a significant global health challenge.
  • Understanding novel molecular markers is crucial for improving patient outcomes.
  • Chordin-like 2 (CHRDL2) has emerged as a gene of interest in cancer research.

Purpose of the Study:

  • To investigate the role and prognostic significance of chordin-like 2 (CHRDL2) in gastric cancer.
  • To explore the association between CHRDL2 expression and the tumor microenvironment, including immune cell infiltration.
  • To elucidate the potential molecular mechanisms underlying CHRDL2's function in gastric cancer development.

Main Methods:

  • Utilized public databases like Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) to identify differentially expressed genes.
  • Analyzed CHRDL2 expression in gastric cancer tissues and correlated it with clinical data using TCGA and KM-plotter.
  • Investigated the relationship between CHRDL2, immune infiltration, and related pathways using the TIMER database and performed Gene Ontology (GO) and KEGG pathway enrichment analyses.

Main Results:

  • CHRDL2 was identified as a differentially expressed gene, with increased cytoplasmic expression in gastric cancer tissues compared to normal tissues.
  • High CHRDL2 expression was significantly associated with worse overall survival (OS), progression-free survival (PFS), and post-progression survival (PPS), and correlated with advanced T stage, race, and pathological characteristics.
  • CHRDL2 expression demonstrated a strong link to immune cell infiltration and was implicated in pathways such as chemokine signaling, MAPK, cell cycle, and PI3K-Akt signaling, suggesting a role in immune evasion and tumor microenvironment modulation.

Conclusions:

  • Decreased CHRDL2 levels are linked to significantly improved patient survival outcomes in gastric cancer.
  • CHRDL2 plays a critical role in facilitating tumor cell immune evasion within the tumor microenvironment.
  • Targeting CHRDL2 may represent a therapeutic strategy to impede gastric cancer progression by influencing cell cycle and apoptosis pathways.

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