Research progress of apelin in acute ischemic brain injury

Acute ischemic brain injury is a cerebrovascular disease with high clinical incidence. An increasing number of preclinical evidence has verified the complex interaction between autophagy disorder and mitochondrial damage. Endoplasmic reticulum stress, oxidative stress and excessive neuroinflammation are the main mechanisms of the neural injury induced by acute cerebral ischemia-reperfusion injury. Apelin and its receptors are widely distributed in various tissues and organs in the human body. Increasing evidence has suggested that apelin has a neuroprotective effect against excitatory toxicity injury, oxidative stress injury and induction of neuronal apoptosis, and it can play a neuroprotective role after acute cerebral ischemia-reperfusion injury. This review summarizes the progress of the neuroprotective effects and mechanisms of apelin, aiming to provide evidence for its therapeutic potential.