ALSUntangled #68: ozone therapy

Area of Science:

• Neurodegenerative Diseases
• Alternative Medicine

Background:

• Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options.
• Alternative and off-label treatments are being explored for managing ALS progression.

Approach:

• This review examines ozone therapy as a potential treatment for ALS.
• Mechanisms of action, preliminary evidence, and safety considerations are discussed.

Key Points:

• Ozone therapy exhibits antioxidant, anti-inflammatory, and mitochondrial effects that may slow ALS progression.
• A non-peer-reviewed study indicated potential benefits in an ALS mouse model.
• One case reported "ALS reversal" with a treatment cocktail including ozone.

Conclusions:

• While promising in preclinical models, there are no clinical trials of ozone therapy for ALS patients.
• Potential serious side effects exist, warranting caution.
• Investigation in ALS cell or animal models is supported, but ozone therapy is not yet recommended for patients.