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Updated: Aug 20, 2025

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
Published on: February 22, 2016
Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ
Nazmus Salehin1,2, Hilary Knowles1, V Pragathi Masamsetti1,2
1Embryology Research Unit, Children's Medical Research Institute, Westmead, NSW, Australia.
Abstract:
The interplay of signalling input and downstream transcriptional activity is the key molecular attribute driving the differentiation of germ layer tissue and the specification of cell lineages within each germ layer during gastrulation. This review delves into the current understanding of signalling and transcriptional control of lineage development in the germ layers of mouse embryo and non-human primate embryos during gastrulation and highlights the inter-species conservation and divergence of the cellular and molecular mechanisms of germ layer development in the human embryo.
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