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Updated: Aug 20, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Branch- and Z-Selective Allylic C-H Amination with Aromatic Amines
Rui Liu1, Meng-Lan Shen1, Lian-Feng Fan1
1Department of Chemistry, University of Science and Technology of China, No.96, Jinzhai Road, Baohe District, Hefei, 230026, P. R.China.
Abstract:
Allylamines are important building blocks in the synthesis of bioactive compounds. The direct coupling of allylic C-H bonds and commonly available amines is a major synthetic challenge. An allylic C-H amination of 1,4-dienes has been accomplished by palladium catalysis. With aromatic amines, branch-selective allylic aminations are favored to generate thermodynamically unstable Z-allylamines. In addition, more basic aliphatic cyclic amines can also engage in the reaction, but linear dienyl allylic amines are the major products.
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