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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jun 14, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

TIMEDB: tumor immune micro-environment cell composition database with automatic analysis and interactive

Xueying Wang^1,2, Lingxi Chen^1,2, Wei Liu¹

¹Department of Computer Science, City University of Hong Kong, Hong Kong, China.

Nucleic Acids Research

|November 18, 2022

Summary

This summary is machine-generated.

Understanding the tumor immune microenvironment (TIME) is crucial for cancer treatment. TIMEDB is a new database offering comprehensive TIME cell-type composition data and analysis tools for researchers.

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Last Updated: Jun 14, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

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Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

Area of Science:

Oncology
Immunology
Bioinformatics

Background:

Deciphering tumor immune microenvironment (TIME) cell-type composition enhances cancer treatment efficacy and patient prognosis.
Microarrays and RNA sequencing generate extensive expression profiles crucial for cancer studies.
Current tools infer TIME composition from bulk expression, enabling heterogeneity investigation.

Purpose of the Study:

To introduce TIMEDB, a novel online database for human TIME cell-type composition.
To address limitations in existing databases regarding data volume, multi-platform integration, and tool integration.

Main Methods:

Compiled manually curated expression profiles, cell-type composition profiles, and clinical information.
Integrated data from 39,706 samples across 546 datasets covering 43 cancer types.
Developed online tools for automatic analysis and interactive visualization of TIME data.

Main Results:

TIMEDB provides a large-scale, integrated resource for TIME analysis.
The database facilitates the investigation of inter- and intra-tumor heterogeneity.
Includes comprehensive data on cell-type composition and associated clinical information.

Conclusions:

TIMEDB serves as a valuable community resource for studying the human tumor microenvironment.
The database and integrated tools empower researchers to advance cancer immunology and treatment strategies.
Facilitates deeper understanding of TIME complexities across diverse cancer types.