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Updated: Aug 20, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Novel approaches to reactivate pertussis immunity
1Center of Vaccinology, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Pertussis vaccines are effective but not fully protective, necessitating new strategies. Research is exploring improved acellular vaccines and novel intranasal options to combat Bordetella pertussis.
Area of Science:
- Immunology
- Vaccinology
- Microbiology
Background:
- Whole cell and acellular pertussis vaccines have significantly reduced infant mortality from Bordetella pertussis.
- Despite high global vaccine coverage, pertussis remains a common vaccine-preventable disease, indicating a need for improved vaccination strategies.
Approach:
- This review examines potential improvements for current pertussis vaccines.
- It also assesses the current status of pertussis vaccine candidates under development.
Key Points:
- New vaccine candidates include acellular pertussis vaccines with detoxified pertussis toxin, novel adjuvants, or delivery systems.
- An intranasally delivered, live attenuated vaccine is also under investigation.
Conclusions:
- Maintaining high childhood vaccination coverage is crucial.
- Increasing vaccination rates in pregnant women, adolescents, and young adults is recommended until safer, more effective, and affordable alternatives are available.
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