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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
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Simvastatin Treatment in Patients with Liver Cirrhosis: a Phase II Randomized Placebo Controlled Trial Shows Reduction in IL-6 Levels.

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Baseline Hemoglobin Predicts Oncologic Outcomes in Intrahepatic Cholangiocarcinoma Treated With Yttrium-90 Radioembolisation: A Retrospective Cohort Study of 136 Patients.

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Impact of age on clinical outcomes among patients with hepatocellular carcinoma: A systematic review and meta-analysis.

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Post-Transjugular Intrahepatic Portosystemic Shunt Right Atrial Pressure and Left Atrial Volume Index Predict Heart Failure and Mortality: Dual Center Experience.

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AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma.

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Metabolic Dysfunction-Associated Steatohepatitis: From Fibrosis-Based Risk Stratification to Emerging Therapeutic Strategies.

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Metabolic Dysfunction-Associated Steatotic Liver Disease and Viral Hepatitis.

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Metabolic Dysfunction Associated Steatohepatitis (MASH) in Oceania, Central America, and the Caribbean.

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Related Experiment Video

Updated: Aug 20, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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Hepatocellular Carcinoma: New Developments.

Previn Ganesan1, Laura M Kulik2

  • 1Northwestern University, 251 East Huron Street, Clarke Conference Room Feinberg Pavilion 13 East, Chicago, IL 60611, USA.

Clinics in Liver Disease
|November 18, 2022
PubMed
Summary
This summary is machine-generated.

This review covers current hepatocellular carcinoma (HCC) diagnosis, staging, and treatment. It also explores ongoing trials and future directions for HCC therapies.

Keywords:
ChemoembolizationCirrhosisHepatocellular carcinomaImmunotherapyLiver cancerRadioembolization

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Area of Science:

  • Hepatology and Oncology
  • Gastroenterology
  • Cancer Research

Background:

  • Hepatocellular carcinoma (HCC) remains a significant global health challenge.
  • Effective management requires up-to-date knowledge of diagnostic and therapeutic advancements.

Purpose of the Study:

  • To provide a comprehensive review of current hepatocellular carcinoma (HCC) practices.
  • To discuss emerging developments and future directions in HCC management.

Main Methods:

  • Literature review of contemporary diagnostic and staging methods for HCC.
  • Analysis of current and emerging treatment modalities for HCC.
  • Review of ongoing clinical trials and future research directions in HCC.

Main Results:

  • Current HCC diagnosis relies on imaging and biomarker integration.
  • Staging systems guide treatment decisions, with liver transplantation, resection, ablation, and systemic therapies being key options.
  • Numerous ongoing trials are investigating novel targeted therapies, immunotherapies, and combination treatments for HCC.

Conclusions:

  • The management of HCC is rapidly evolving, with personalized treatment strategies becoming increasingly important.
  • Continued research and clinical trials are crucial for improving outcomes in hepatocellular carcinoma (HCC).
  • A multidisciplinary approach is essential for optimal HCC patient care.