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Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

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Chronic Pain: Prevalence and Management

Christopher P Carroll1, Amanda M Brandow2

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD 21287, USA.

Hematology/Oncology Clinics of North America
|November 18, 2022
PubMed

Insights

Chronic pain significantly impacts sickle cell disease (SCD) patients, especially adults. New research and targeted clinical trials are crucial for effective chronic SCD pain management.

Area of Science:

  • Hematology
  • Pain Medicine
  • Clinical Research

Background:

  • Chronic pain is a prevalent and debilitating complication in sickle cell disease (SCD).
  • Pain in SCD significantly increases with age and affects a majority of adult patients.
  • The underlying mechanisms of chronic SCD pain differ from acute pain episodes, necessitating distinct therapeutic strategies.

Purpose of the Study:

  • To highlight the distinct nature of chronic sickle cell disease pain.
  • To emphasize the lack of dedicated clinical trials for chronic SCD pain.
  • To advocate for further research into the pathophysiology and treatment of chronic SCD pain.

Main Methods:

  • This study is a review of current understanding and clinical practice regarding chronic SCD pain.
  • It synthesizes existing literature on SCD pathophysiology and pain management.
  • It identifies gaps in research and clinical trial data for chronic pain in SCD.

Main Results:

  • Chronic pain is a common and progressive issue in adult SCD patients.
  • Current treatment approaches for chronic SCD pain are often extrapolated from other chronic pain conditions.
  • There is a significant deficit in clinical trials specifically investigating therapies for chronic SCD pain.

Conclusions:

  • Chronic pain in sickle cell disease requires a specialized approach distinct from acute pain management.
  • Further investigation into the specific causes of chronic SCD pain is essential.
  • The development and execution of clinical trials focused on chronic pain therapies in SCD are imperative for improving patient outcomes.

Keywords:
Chronic painNonpharmacologic pain treatmentOpioidSickle cell disease

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