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Related Experiment Video

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Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications.

Naira Baregamian1, Konjeti R Sekhar1, Evan S Krystofiak2

  • 1Division of Surgical Oncology & Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN.

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Researchers developed 3D patient-derived organoids for endocrine tumors like thyroid and adrenal cancers. These models mimic tumor microenvironments, offering new avenues for cancer research and treatment development.

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Area of Science:

  • Endocrinology
  • Cancer Biology
  • 3D Organoid Technology

Background:

  • 3D patient-derived organoids are revolutionizing cancer biology.
  • Need for endocrine tumor organoid models for thyroid, adrenal, and parathyroid neoplasms.
  • Aim to engineer functional 3D endocrine organoids for research.

Purpose of the Study:

  • To engineer functionally intact 3D endocrine patient-derived organoids.
  • To expand in vitro and translational applications in endocrine research.

Main Methods:

  • Established 3D endocrine organoid models from patient fine needle aspirates.
  • Included papillary thyroid carcinoma, medullary thyroid carcinoma, adrenocortical carcinoma, and parathyroid/adrenal neoplasms.
  • Performed multiplatform analyses for oncoimmunology, autofluorescence, and radiosensitization.

Main Results:

  • Successfully modeled and analyzed the endocrine microenvironment in 3D culture.
  • Organoids recapitulated tumor microenvironment morphologically and functionally.
  • Maintained cytokine production and near-infrared autofluorescence properties.

Conclusions:

  • Novel 3D endocrine organoid models offer an alternative to 2D systems.
  • These models have broad in vitro and translational applications.
  • Potential applications include endocrine oncoimmunology research.