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Geometry design for a fully insertable glucose biosensor with multimodal optical readout.

Jesse Fine¹, Gerard L Coté^1,2, Michael J McShane^1,2,3

¹Texas A&M University, Department of Biomedical Engineering, College Station, Texas, United States, United States.

Journal of Biomedical Optics

|November 19, 2022

Summary

This summary is machine-generated.

Optimized insertable optical continuous glucose monitors (CGMs) improve signal detection for diabetes management. Computational modeling confirmed a new biosensor design enhances luminescent output and ensures accurate glucose monitoring in vivo.

Keywords:

biophotonics fluorescence implanted devices lifetime phosphorescence spectroscopy wearable sensors

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Area of Science:

Biomedical Engineering
Optical Biosensors
Diabetes Technology

Background:

Insertable optical continuous glucose monitors (CGMs) require small form factors for effective tissue signal transmission.
Optimizing biosensor geometry is crucial for meeting performance criteria in fully insertable CGMs.
Multimodal repeating unit (barcode) designs show promise for insertable optical CGM technology.

Purpose of the Study:

Evaluate the geometry of a fully insertable multimodal optical biosensor.
Assess optical output and in vivo species diffusion characteristics.
Optimize biosensor design for enhanced performance in continuous glucose monitoring.

Main Methods:

Utilized Monte Carlo modeling to assess luminescent output of biosensor designs.
Analyzed sensitivity to displacement, overall size, and repeating unit dimensions.
Employed experimentally validated multiphysics modeling for diffusion and reaction analysis.

Main Results:

A stacked cylinder biosensor (4.4 mm length, 0.36 mm repeating units) demonstrated superior luminescent output compared to existing designs.
Biosensors with enzymatic elements did not significantly impact local glucose diffusion.
Computational modeling guided the design for sufficient optical output and chemical diffusion.

Conclusions:

Computational modeling successfully designed an insertable optical CGM with adequate in vivo performance.
The optimized biosensor geometry ensures reliable optical signal and accurate glucose diffusion profiles.
This work advances the development of fully insertable optical CGMs for diabetes management.