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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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The effect of SARS-CoV-2 infection on cardiac function in post-COVID-19 survivors: A systematic review and

Masoud Rahmati1, Ai Koyanagi2,3,4, Ebrahim Banitalebi5

  • 1Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.

Journal of Medical Virology
|November 19, 2022
PubMed

Insights

COVID-19 survivors show persistent cardiac dysfunction, including reduced ejection fraction and increased left ventricular mass, even one year post-infection. These cardiovascular changes are more pronounced in patients with severe acute SARS-CoV-2 infection.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Longitudinal effects of SARS-CoV-2 on cardiac structure and function remain unclear.
  • Understanding post-COVID-19 cardiovascular sequelae is crucial for patient management and public health strategies.

Approach:

  • Systematic review and meta-analysis of 21 studies (2394 individuals) published up to August 2022.
  • Pooled analysis of cardiac structure and function outcomes in COVID-19 survivors compared to controls.
  • Subgroup analysis based on COVID-19 severity (acute phase) and chronic outcomes.

Key Points:

  • Post-COVID-19 associated with reduced left ventricular ejection fraction, end-diastolic volume, stroke volume, mitral annular plane systolic excursion, global longitudinal strain, and right ventricular function.
  • Increased left ventricular mass observed in COVID-19 survivors.
  • Cardiac impairment persisted beyond one year, particularly in patients with a history of intensive care unit admission.

Conclusions:

  • SARS-CoV-2 infection leads to significant and persistent cardiac dysfunction in recovered individuals.
  • Severity of acute COVID-19 influences the extent of long-term cardiac impairment.
  • Further research is needed to elucidate the underlying biological mechanisms of these cardiovascular consequences.

Keywords:
COVID-19SARS-CoV-2cardiac functioncardiac structuremeta-analysis

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