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Association between microRNA-146a rs2910164 polymorphism and coronary heart disease: An updated meta-analysis

Qinxue Bao1, Rui Li, Chengfeng Wang

  • 1Department of Cardiology, Dayi County People's Hospital, Chengdu, Sichuan, China.

Medicine
|November 19, 2022
PubMed

Insights

The single nucleotide polymorphism miR-146a rs2910164 G allele is linked to a reduced risk of coronary heart disease (CHD). This meta-analysis confirms its association with lower CHD susceptibility, particularly in the Chinese population.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Epidemiology
  • Atherosclerosis Research

Background:

  • Coronary heart disease (CHD) is a major manifestation of atherosclerosis with high morbidity.
  • MicroRNA (miRNA)-146a rs2910164 polymorphism has been implicated in CHD risk, but findings are inconsistent.
  • This meta-analysis aimed to clarify the association between rs2910164 and CHD susceptibility.

Approach:

  • A comprehensive literature search was conducted across major databases until April 2022.
  • Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the correlation.
  • Bonferroni correction and trial sequential analysis were employed to ensure result reliability.

Key Points:

  • The meta-analysis included 18 studies with 6859 cases and 8469 controls.
  • The G allele at rs2910164 was significantly associated with decreased CHD risk across multiple models.
  • Subgroup analysis indicated a lower CHD risk in the Chinese population with the G allele or GG genotype.

Conclusions:

  • MicroRNA (miRNA)-146a rs2910164 polymorphism is potentially associated with reduced coronary heart disease susceptibility.
  • The G allele appears protective against CHD, especially in specific populations and genetic models.
Abstract

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