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A case report of small cell ovarian neuroendocrine carcinoma combined with immunochemotherapy

Yuan-Xue Zhu1,2, Xiang-Peng Gao3, Lei Xin4

  • 1Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei, P.R. China.

Medicine
|November 19, 2022
PubMed
Abstract

Insights

This study explored tirelizumab plus etoposide and cisplatin chemotherapy for small cell ovarian neuroendocrine carcinoma. The combination showed promising efficacy and safety for this rare cancer.

Area of Science:

  • Oncology
  • Neuroendocrine Tumors
  • Immunotherapy

Background:

  • Small cell ovarian neuroendocrine carcinoma is a rare malignancy with poor prognosis.
  • Limited standardized treatment options exist for this condition.
  • Efficacy of combined immunotherapy and chemotherapy is not well-documented.

Observation:

  • A patient with small cell ovarian neuroendocrine carcinoma received tirelizumab (a PD-1 inhibitor) with etoposide and cisplatin chemotherapy (EP).
  • Treatment involved initial EP cycles followed by maintenance immunotherapy.
  • Efficacy was assessed every two cycles, with partial response (PR) noted.

Findings:

  • The combination of tirelizumab and EP demonstrated partial response (PR) in the patient.
  • Immunomaintenance therapy was successfully administered after initial treatment.
  • The treatment regimen was well-tolerated, indicating a favorable safety profile.

Implications:

  • Tirelizumab plus EP chemotherapy may represent an effective therapeutic strategy for small cell ovarian neuroendocrine carcinoma.
  • This approach could offer a new treatment option for patients with this rare and aggressive cancer.
  • Further clinical investigation is warranted to confirm these findings in a larger cohort.

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