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Prognostic potential of miR-144 in various cancers: A meta-analysis

Chong-Yang Jia1, Yan He1, Shi-Nan Wu2,3

  • 1Department of General Surgery, the Second Hospital of Lanzhou, Lanzhou, China.

Medicine
|November 19, 2022
PubMed
Abstract

Insights

Low miR-144 expression is linked to better overall survival in various cancers, particularly urinary system cancers. This microRNA (miRNA) shows potential as a prognostic biomarker for cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • MicroRNA-144 (miR-144) has emerged as a potential prognostic biomarker in cancer.
  • Previous studies on its role in various cancers yielded inconsistent conclusions.
  • This meta-analysis aimed to clarify the prognostic significance of miR-144 in cancer patients.

Approach:

  • A systematic literature search was conducted across PubMed, EMBASE, and Web of Science databases.
  • Data from 15 eligible studies, including 1846 participants, were analyzed.
  • Hazard ratios (HR) and odds ratios (OR) with 95% confidence intervals (CI) were pooled to assess prognostic value.

Key Points:

  • Low miR-144 expression was significantly associated with favorable overall survival across various cancers (HR: 0.68, 95% CI: 0.53-0.88).
  • miR-144 demonstrated enhanced predictive value in urinary system cancers (HR: 0.48, 95% CI: 0.35-0.64).
  • Low miR-144 expression correlated with larger tumor diameter, advanced tumor stage (III-IV), and deeper invasion (T3-T4).

Conclusions:

  • MicroRNA-144 (miR-144) shows promise as a prognostic biomarker in oncology.
  • Its expression levels can predict patient survival and correlate with tumor progression markers.
  • Further research is warranted to fully elucidate the clinical utility of miR-144 in cancer management.

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