Related Experiment Video

Updated: Aug 20, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

270

Role of renal tubular programed cell death in diabetic kidney disease

Xiaojun Zhou1,2, Chunmei Xu3,4,5, Jianjun Dong6

  • 1Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China.

Diabetes/Metabolism Research and Reviews
|November 19, 2022
PubMed

Insights

Diabetic kidney disease involves tubular damage and programmed cell death (PCD). Targeting tubular PCD pathways offers potential therapeutic strategies for diabetic kidney disease treatment.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pathology

Background:

  • Diabetic kidney disease (DKD) pathogenesis is complex, with tubular damage being a key factor in early renal dysfunction.
  • Programmed cell death (PCD) abnormalities in renal tubules are increasingly recognized as crucial in DKD development.

Purpose of the Study:

  • To review the current understanding of DKD mechanisms, focusing on tubular PCD.
  • To explore the therapeutic potential of targeting tubular PCD pathways in DKD.

Main Methods:

  • Literature review focusing on apoptosis, autophagy, and pyroptosis in DKD.
  • Analysis of studies investigating the role of tubular cell death in DKD pathogenesis.

Main Results:

  • Tubular damage and altered PCD are central to early DKD.
  • Apoptosis, autophagy, and pyroptosis are significant PCD pathways implicated in DKD.

Conclusions:

  • Understanding tubular PCD mechanisms is vital for DKD treatment.
  • Targeting specific PCD pathways presents a promising therapeutic avenue for managing diabetic kidney disease.
Keywords:
apoptosisautophagydiabetic kidney diseaseprogramed cell deathpyroptosisreview

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