Related Experiment Video

Updated: Aug 20, 2025

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

3.7K

Anticoagulation alone as an effective and safe antithrombotic therapy in LVAD: When less is more

Vincenzo Tarzia1, Chiara Tessari1, Lorenzo Bagozzi1

  • 1Cardiac-Surgery-Unit, Department of Cardio-Thoracic-Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Current Problems in Cardiology
|November 19, 2022
PubMed

Insights

Aspirin avoidance in HeartMate3 patients significantly reduced bleeding events without increasing clotting risks, demonstrating a safe and effective anticoagulation strategy for improved hemocompatibility.

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Hematology

Background:

  • HeartMate3 left ventricular assist device (LVAD) recipients require careful antithrombotic management to balance thrombosis and bleeding risks.
  • Optimizing anticoagulation regimens is crucial for long-term LVAD performance and patient safety.

Purpose of the Study:

  • To assess the safety and efficacy of anticoagulation strategies in HeartMate3 patients.
  • To compare hemocompatibility-related adverse events (HRAEs) and hemocoagulative markers between patients on warfarin plus aspirin versus warfarin alone.

Main Methods:

  • A prospective study divided 50 HeartMate3 patients into two groups: Group-1 (warfarin + aspirin) and Group-2 (warfarin alone).
  • Evaluated HRAEs, hemocompatibility score (HCS), and laboratory markers over a median follow-up of 590 days.

Main Results:

  • Significantly fewer HRAEs occurred in Group-2 (2%) compared to Group-1 (34%) (P < 0.001).
  • Group-1 had a higher net HCS (24 points) than Group-2 (1 point) (P = 0.023).
  • Hemocoagulative markers remained stable, with no intergroup differences except for the ASPI-test (P = 0.003).

Conclusions:

  • HeartMate3 demonstrates high hemocompatibility irrespective of the antithrombotic regimen.
  • Omitting aspirin from the antithrombotic therapy in HeartMate3 patients is a safe and effective strategy, reducing hemorrhagic events without elevating thrombotic risk.

More Related Videos

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.3K
In Vitro Thrombosis Test for Ventricular Assist Devices09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

746

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
16
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
27
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
834
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.3K
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
188
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
32