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Related Experiment Video

Updated: Aug 20, 2025

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
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Altered hearing function in mice with implanted cranial windows.

Nataša Jovanović1, Štěpánka Suchánková2, Minseok Kang2

  • 1Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4 - Krč, Czech Republic; Second Faculty of Medicine, Charles University, 150 06 Prague, Czech Republic.

Neuroscience Letters
|November 19, 2022
PubMed
Summary

Cranial window surgery impairs auditory function in mice, affecting hearing thresholds, cochlear function, and auditory processing. These long-term effects impact auditory brainstem responses and require consideration in neuroimaging studies.

Keywords:
AuditoryChronic cranial windowHearing lossSurgery trauma

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Surgical Techniques

Background:

  • Cranial window (CW) implantation is vital for in vivo optical imaging of cortical activity.
  • The invasive nature of CW surgery may induce neurological side effects.
  • Potential impacts on sensory systems, particularly auditory function, remain under-investigated.

Purpose of the Study:

  • To evaluate the functional consequences of unilateral CW surgery on the auditory system in C57BL6 mice.
  • To assess both electrophysiological and behavioral changes in auditory function post-surgery.

Main Methods:

  • Electrophysiological recordings of auditory brainstem responses (ABRs).
  • Measurement of distortion product otoacoustic emissions (DPOAEs) to assess cochlear function.
  • Behavioral testing, including gap prepulse inhibition of the acoustic startle reflex (GPIAS).

Main Results:

  • One week post-surgery, mice showed elevated ABR thresholds and reduced amplitudes.
  • Decreased DPOAEs indicated cochlear function deterioration.
  • Reduced GPIAS suggested auditory processing deficits or potential tinnitus.

Conclusions:

  • Unilateral CW surgery induces significant, long-term auditory system dysfunction in mice.
  • Observed changes include impaired cochlear function and altered auditory processing.
  • These findings necessitate careful consideration when interpreting optical imaging data from CW models.