Clinical considerations in Parkinson's disease cell therapy
Jun Xue1, Yifan Wu1, Yuting Bao1
1Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Neurosurgical Institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China.
Ageing Research Reviews
|November 19, 2022
Summary
Cell replacement therapy shows promise for Parkinson's disease (PD). Overcoming challenges in surgical procedures, medication, graft survival, and follow-up is crucial for clinical application in PD patients.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Clinical Neurology
Background:
- Parkinson's disease (PD) is a progressive neurodegenerative disorder.
- Current treatments manage symptoms but do not halt disease progression.
- Cell replacement therapy offers a potential disease-modifying approach for PD.
Purpose of the Study:
- To review the current status of cell replacement therapy for Parkinson's disease.
- To identify critical requirements for translating cell therapy into clinical practice for PD.
- To outline guideposts for advancing cell therapy in the Parkinson's clinic.
Main Methods:
- Literature review focusing on cell therapy for PD.
- Analysis of key challenges and requirements for clinical implementation.
- Discussion of surgical procedures, perioperative management, graft survival, and follow-up measures.
Main Results:
- Significant barriers remain for clinical application of cell therapy in PD.
- Standardized surgical techniques, medication protocols, and long-term graft assessment are essential.
- Clinically meaningful follow-up measures are needed to evaluate efficacy and safety.
Conclusions:
- Cell replacement therapy holds potential for Parkinson's disease treatment.
- Addressing surgical, pharmacological, and monitoring challenges is paramount.
- Establishing clear guidelines will facilitate the clinical translation of cell therapy for PD patients.
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