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Functional diversification of heat shock factors
Dániel Kovács1, Márton Kovács1, Saqib Ahmed1
1Department of Genetics, Institute of Biology, Eötvös Loránd University, Pázmány Péter sétány 1/c, Budapest, H-1117, Hungary.
Biologia Futura
|November 19, 2022
Summary
Heat shock transcription factors (HSFs) regulate cellular proteostasis and diverse biological processes. This review explores HSF family functions and their diversification, offering insights into aging, development, and disease.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Heat shock transcription factors (HSFs) are key regulators of cellular stress responses.
- In vertebrates, seven HSF family members (HSF1-HSFY) exist, with HSF1/2 linked to heat shock and HSF4 to development.
- The functions of other HSF family members remain less understood.
Purpose of the Study:
- To review current knowledge on the functions of HSF family members.
- To explore the mechanisms behind the functional diversification of HSFs.
- To highlight the roles of HSFs in proteostasis, aging, development, and diseases like cancer and neurodegeneration.
Main Methods:
- Literature review of HSF family functions.
- Analysis of gene regulation by HSFs, including chaperone expression.
- Examination of HSF involvement in various biological processes and pathologies.
Main Results:
- HSFs regulate protein homeostasis (proteostasis) beyond heat shock response.
- HSFs influence critical processes: aging, development, cell proliferation, and differentiation.
- Dysregulation of HSFs is implicated in neurodegeneration and cancer.
Conclusions:
- HSFs exhibit diverse functions beyond their canonical roles.
- Understanding HSF functional diversification is crucial for comprehending their roles in health and disease.
- Further research is needed to fully elucidate the roles of less-studied HSF family members.
Keywords:
Functional diversificationHeat shock factorsHeat shock proteinsHeat shock responseMolecular evolutionMore Related Videos
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