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Depth-Resolved Localization Microangiography in the NIR-II Window.

Quanyu Zhou1,2, Daniil Nozdriukhin1,2, Zhenyue Chen1,2

  • 1Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.

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Summary
This summary is machine-generated.

This study introduces a novel 3D deep-tissue microangiography technique using stereovision and super-resolution imaging. The method achieves high-resolution visualization of microvascular networks up to 4mm deep in tissue.

Keywords:
fluorescence microscopylocalization imagingmicroangiographysecond near-infrared spectrumstereovision

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Area of Science:

  • Biomedical Imaging
  • Optical Microscopy
  • Vascular Biology

Background:

  • Characterizing microvascular alterations necessitates high-resolution 3D imaging for morphological and functional data.
  • Current optical microscopy methods for microangiography face limitations in field of view, spatial resolution, and penetration depth due to light scattering.

Purpose of the Study:

  • To develop a novel volumetric deep-tissue microangiography technique overcoming existing resolution and depth limitations.
  • To enable detailed visualization and functional assessment of microvascular networks in deep tissues.

Main Methods:

  • Employs stereovision combined with super-resolution localization imaging.
  • Utilizes fluorescent particle tracking in the second near-infrared window (NIR-II, 1000-1700 nm).
  • Adds the third dimension via triangulation and stereo-matching from two short-wave infrared cameras in a dual-view configuration.

Main Results:

  • Achieves high-resolution imaging up to 4 mm deep in turbid media, preserving resolution.
  • Demonstrates detailed 3D visualization of microvascular networks.
  • Enables accurate quantification of blood flow.
  • Successfully performed transcranial microangiography of the entire murine cortex at capillary resolution.

Conclusions:

  • The proposed stereovision-based super-resolution microangiography significantly advances deep-tissue imaging capabilities.
  • This method provides unprecedented detail for studying microvascular alterations and blood flow in vivo.