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Updated: Aug 20, 2025

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
High-Quality Artery Monitoring and Pathology Imaging Achieved by High-Performance Synchronous Electrical and Optical
Zeyu He1, Xiaoyang Du1, Caijun Zheng1
1School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 610054, P. R. China.
Abstract:
Near-infrared organic photodetectors (NIR-OPDs) are significant technologies in emerging biomedicine applications for uniquely wearable, noninvasive, low-cost advantages. However, biosignals are weak and changing rapidly so practical biodetection and bioimaging are still challenging for NIR-OPDs. Herein, high-performance NIR-OPDs with synchronous optical output are realized by recombining anode-injected electrons with photogenerated holes on emitters. Owing to high detection performance of 4.5 × 1012 Jones detectivity and 120 kHz -3 dB bandwidth, five arteries are monitored by transmission-type method and cardiac cycle is analyzed. Importantly, the synchronous optical output is direct emission demonstrating outstanding photon conversion efficiency approaching 20% and luminance signal-to-noise ratio over 8000. Consequently, pathology imaging is directly developed without complex readout circuits and arrays from which squamous metaplasia of cervix and carcinoma of large intestine are observed clearly. The NIR-OPD demonstrates strategies for high-performance synchronous electrical/optical output and directly imaging. Biomedicine applications implemented here are high level, representing important steps for NIR-OPDs toward providing clues for clinical diagnosis.
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