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Precision medicine: Ray of hope in overcoming cancer multidrug resistance

Pankaj Musyuni1, Jing Bai2, Afsana Sheikh3

  • 1Centre for Advanced Formulation and Technology (CAFT), Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, Govt. of NCT of Delhi, New Delhi 110017, India.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|November 20, 2022
PubMed

Insights

Multi-drug resistance (MDR) in cancer therapy leads to treatment failure. Precision medicine offers a targeted approach to overcome MDR by tailoring treatments to individual tumor molecular profiles, improving outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Multi-drug resistance (MDR) is a primary cause of chemotherapy failure.
  • Tumor microenvironment, genetic alterations, cellular changes, and tumor heterogeneity contribute to MDR.
  • Understanding the human genome is crucial for developing targeted cancer therapies.

Purpose of the Study:

  • To discuss the causes of MDR in cancer.
  • To highlight the role of precision medicine in overcoming MDR.
  • To review the limitations and future prospects of precision medicine in oncology.

Main Methods:

  • Review of current literature on MDR and precision medicine.
  • Analysis of molecular mechanisms underlying tumor resistance.
  • Exploration of precision medicine strategies in oncology.

Main Results:

  • Precision medicine enables therapy design based on individual molecular alterations and tumor environments.
  • This approach facilitates early detection, targeted treatment, and improved patient survival.
  • Precision medicine can reduce the toxicity associated with conventional chemotherapy.

Conclusions:

  • Precision medicine represents a revolutionary approach to cancer therapy, particularly in overcoming MDR.
  • Further research is needed to address limitations and fully realize the potential of precision medicine.
  • Personalized therapeutic strategies hold significant promise for improving cancer treatment efficacy and patient care.
Keywords:
CancerGenomic profileInnovationMultidrug resistancePrecision medicineTechnology transfer

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